PROGRAM APPLICATION FOR THE DETERMINATION OF THE STATE OF THE PATIENTS WITH JUVENILE RHEUMATOID ARTHRITIS IN THE REMOTE PERIOD
Keywords:juvenile rheumatoid arthritis, prediction model, regression analysis, methods of the operations study
The research considers the process of the elaboration of the program application for the assessment of the remote state of the patients, who in their childhood were made a diagnosis of the juvenile rheumatoid arthritis. The complexity of the given task is that the patients were initially evaluated at an early age, then they got the corresponding treatment, which must be prescribed individually for each patient, as a result of the treatment the symptoms of the disease must disappear or be minimal. For the assessment of the degree of the disease indices JADI-A (joint arthritis damage index-articular)and JADI-Е (joint arthritis damage index-extra-articular) are used. Data of 289 patients are used in the research.
Methods of linear programming are proposed to be used for the construction of the system of regression equations which allow to predict the numerical characteristics of the patient`s state in the adult period, taking into account the performed treatment. The structure of the models system consists of the models, which evaluated the state JADI-A and JADI-Е in the remote period and the additional control parameters. These are indices that must be limited in a certain way. The presented models can also be used for the selection of the patient-specific treatment strategy, which, taking into account the initial state of the patient will allow to minimize the number of the articular and extra-articular damages. These models were tested for accuracy by means of the determination coefficient, all of them showed accuracy greater than 0.9 on the test data, this proves their high quality. All the models were used as the basis of the program application, which can be used for the storage of the patients` data at all the stages of the examination and for the assessment of the patients` state. This program product has been developed on the programming language R, using the framework Shiny. Using the application doctors will be able to observe the patient, store the results of the control and perform the assessment of the patient`s state.